Good morning!
I have older Spyder2Express and newer display DELL U2412M
Recently I upgraded to Windows 10 and since then I did not noticed that the color is very much off.
It looks ok, but will I benefit anything by calibrating the display with the Spyder2Express?
Thanks

You will always benefit from calibration but don't expect your old Spyder2Express to do it. I tried to do the same thing when I upgraded to 8.1 and the software wouldn't run so I upgraded to Color Munki.

Thanks!
I looked up Colormunki, and it is $170 at Amazon
Is there more economical solution for color calibration?

I don't believe the Spyder 2 works very well with LED backlights, and it's a pretty old bit of kit, designed to work with CRT's and CFL LCD's I wouldn't be surprised if it is not totally compatible with Windows 10.
I moved to a Spyder 4 when I got wide gamut monitors and one with an LED back lights.

I had come across an open source software project which apparently could use most versions of the Spyder hardware, and I was hoping it would prove to be a more reliable option than the software that came with my Spyder 4 puck (I found it was prone to random lockups and was just a pain to use at times). However I never got around to digging into it, and now I'm blanking on the project name. Wasn't the most user friendly bit of software as well, so may be a complete bust for the OP, but possibly worth a try if you're not interested in dropping any money on new hardware/software.

Here is the software that might use the Spyder puck. Have no used it as I just upgraded to the Spyder5Pro.
http://www.homecinema-fr.com …tre-hcfr/hcfr-colormeter/
From the website:
Latest version (v3.x) supports our Probe as well as a “simulated” one (so you can learn even if you don’t yet have a probe). This latest version also support of some well known third party probes :
i1 Display 1, 2, 3 et LT
i1 Pro
Colormunki Photo, Design et Display
Spyder 2, 3 et 4
Huey
ColorBob

Sorry. Also found this website that says it supports different pucks including the Spyder2. Have no knowledge or experience, only posting what was found with a Google search.
http://dispcalgui.hoec​h.net/#requirements
From their website:
Colorimeters
CalMAN X2 (treated as i1 Display 2)
Datacolor/ColorVision Spyder 2
Datacolor Spyder 3 (since Argyll CMS 1.1.0)
Datacolor Spyder 4 (since Argyll CMS 1.3.6)
Datacolor Spyder 5 (since Argyll CMS 1.7.0)
...

Here is another open source project that will support the older pucks. Initially installing the Argyll software is fairly complex, especially with a spyder device, but I have heard good things about the results. That said, it is a bit of a mystery how well the old spyder device will work on a newer technology monitor, regardless of the software being used.
http://www.argyllcms.c​om/
http://dispcalgui.hoec​h.net/ (Graphical Interface for the argyll software)

I just got an email recently from Datacolor (the Spyder people) offering me a discount if I upgrade to their newest colorimeter. I didn't use it, so I deleted it.. but it seems like it was 30% off or so. Might be worth your while to check w/ them regarding an upgrade from an older device. You'll get the newest one our there, and it might still save you some money. I think it said all you need is the serial # of your device (usually on the USB plug).

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Yea I get the same from them every time they have a new one out. Its never a good deal as almost always better prices can be had elsewhere.